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JAMA Oncol. Objective: To analyze and compare the effectiveness of different maintenance regimens in NDMM via a network meta-analysis.

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From screened records, 11 studies were included. The evidence was synthesized using a network meta-analysis NMA.

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To allow comparison of all treatments, no maintenance was selected as common comparator and the effect of placebo was assumed to be the same as no treatment.

: Eleven trials and 8 treatments including a total of participants were included. By PFS analysis, lenalidomide-based regimens lenalidomide-prednisone, lenalidomide alone were identified as the most effective options HR, 0.

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